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malaria parasite

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Parasite (28) Akt (1) AMPK (1) Antibiotic (3) Apoptosis (1) Autophagy (1) Bacterial (2) Bcl-2 Family (1) Caspase (1) Cathepsin (2) Cytochrome P450 (3) Dihydroorotate Dehydrogenase (1) DNA Methyltransferase (1) EGFR (1) Endogenous Metabolite (1) HCV (1) Histone Methyltransferase (1) Huntingtin (1) Isotope-Labeled Compounds (2) mTOR (1) Na+/K+ ATPase (1) PARP (1) PKA (1) PKC (1) Reactive Oxygen Species (1)
By Research Areas:	Cancer (6) Infection (25) Inflammation/Immunology (1) Neurological Disease (1)

By Targets:

Parasite (28)

Akt (1)

AMPK (1)

Antibiotic (3)

Apoptosis (1)

Autophagy (1)

Bacterial (2)

Bcl-2 Family (1)

Caspase (1)

Cathepsin (2)

Cytochrome P450 (3)

Dihydroorotate Dehydrogenase (1)

DNA Methyltransferase (1)

EGFR (1)

Endogenous Metabolite (1)

HCV (1)

Histone Methyltransferase (1)

Huntingtin (1)

Isotope-Labeled Compounds (2)

mTOR (1)

Na+/K+ ATPase (1)

PARP (1)

PKA (1)

PKC (1)

Reactive Oxygen Species (1)

By Research Areas:

Cancer (6)

Infection (25)

Inflammation/Immunology (1)

Neurological Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Parasite

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-151561

WM382	Parasite	Infection
WM382 is an orally active and potent dual plasmepsin IX/X (PMIX/X) inhibitor with IC₅₀ values of 1.4 nM and 0.03 nM, respectively. WM382 has robust in vivo efficacy at multiple stages of the malaria parasite life cycle and an excellent resistance profile .

HY-N8513

Brevicompanine B	Parasite	Infection
Brevicompanine B, a diketopiperazine alkaloid, is an antiplasmodial agent. Brevicompanine B is active against the malaria parasite Plasmodium falciparum 3D7 IC₅₀ of 35 mg/mL .

HY-D1532

DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS	Parasite	Others
DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS is a fluorescent dye, and can be applied in a fluorogenic substrate for an aspartyl proteinase from human malaria parasite .

HY-N10624

Koshidacin B	Parasite	Infection
Koshidacin B is an antiplasmodial cyclic tetrapeptide with antiplasmodial activity against *P. falciparum* FCR3 and K1 strain with IC₅₀ values of 0.89 and 0.83 μM, respectively. Koshidacin B suppresses malaria parasites in vivo, it can be used for the research of parasites infection .

HY-103397

Nanaomycin A	DNA Methyltransferase Parasite	Infection Cancer
Nanaomycin A is the first selective DNMT3B inhibitor with an IC₅₀ of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells . Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC₈₀ value of 33.1 nM .

HY-117015

Purfalcamine	Parasite	Infection
Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC₅₀ of 17 nM and an EC₅₀ of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage .

HY-121493

TM2-115

Histone Methyltransferase Parasite Infection

TM2-115 inhibits malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death .
HY-W010986

Fmoc-N-Me-Phe-OH

Parasite Infection

Fmoc-N-Me-Phe-OH is a peptide inhibitor of Malaria Parasite .
HY-132929

TCMDC-125431

Parasite Infection

TCMDC-125431 is a novel disruptor of the malaria parasite calcium dynamics but minimally inhibits heme crystallization.
HY-132930

TCMDC-136230

Parasite Infection

TCMDC-136230 is a novel disruptor of the malaria parasite calcium dynamics but minimally inhibits heme crystallization.

TM2-115	Histone Methyltransferase Parasite	Infection
TM2-115 inhibits malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death .

Fmoc-N-Me-Phe-OH	Parasite	Infection
Fmoc-N-Me-Phe-OH is a peptide inhibitor of Malaria Parasite .

TCMDC-125431	Parasite	Infection
TCMDC-125431 is a novel disruptor of the malaria parasite calcium dynamics but minimally inhibits heme crystallization.

TCMDC-136230	Parasite	Infection
TCMDC-136230 is a novel disruptor of the malaria parasite calcium dynamics but minimally inhibits heme crystallization.

HY-145327

Antimalarial agent 7	Na+/K+ ATPase Parasite	Infection
Antimalarial agent 7 is a potent inhibitor of PfATP4. PfATP4 is an essential ion pump on the parasite surface. Antimalarial agent 7 has the potential for the research of human malaria parasite, Plasmodium falciparum .

HY-N10096

Epoxyazadiradione	Parasite	Infection
Epoxyazadiradione is a limonoid purified from neem (Azadirachta indica) fruits. Epoxyazadiradione inhibits the tautomerase activity of MIF of both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF)) non-competitively in a reversible fashion (K_i, 2.11-5.23 μM). Epoxyazadiradione has the potential against proinflammatory reactions induced by MIF of both malaria parasites and human .

HY-N10928

Lettowienolide

Parasite Infection

Lettowienolide, a geranylbenzoquinonoid, exhibits mild in vitro activity against the Plasmodium falciparum malaria parasite (IC₅₀~20 μg/mL) .

Lettowienolide	Parasite	Infection
Lettowienolide, a geranylbenzoquinonoid, exhibits mild in vitro activity against the Plasmodium falciparum malaria parasite (IC₅₀~20 μg/mL) .

HY-N9991

5-Hydroxy-3,7-dimethoxyflavone	Others	Others
5-Hydroxy-3,7-dimethoxyflavone (compound 1) can be isolated from Kaempferia parviflora, but has no significant toxicity to malaria parasites, fungi, and bacteria .

HY-13832

Atovaquone 1 Publications Verification Atavaquone	Parasite Cytochrome P450 Antibiotic Bacterial	Infection Cancer
Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC₅₀ values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia .

HY-156028

FIKK9.1-IN-1	Parasite	Infection
FIKK9.1-IN-1 (Compound 1) is a FIKK9.1 inhibitor. FIKK9.1-IN-1 interacts with the ATP?binding residues in FIKK9.1. FIKK9.1-IN-1 is an antimalarial agent (IC₅₀: 2.68 μg/mL) and disrupts the parasite life cycle and leads to the death of parasites .

HY-13832S2

Atovaquone-d5 Atavaquone-d₅	Isotope-Labeled Compounds Parasite Cytochrome P450 Antibiotic	Infection
Atovaquone-d₅ is the deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

HY-13832S3

cis-Atovaquone-d4 cis-Atavaquone-d₄	Isotope-Labeled Compounds Parasite Cytochrome P450 Antibiotic	Infection
cis-Atovaquone-d₄ is deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

HY-148035

Plm IV inhibitor-2	Parasite	Infection
Plm IV inhibitor-2 (compound 3) is a potent digestive vacuole plasmepsins IV (Plm IV) inhibitor with IC₅₀ values of 24 nM, 70 nM and 0.3 μM for Plm IV, II and I, respectively. Plm IV inhibitor-2 can be used to research malaria caused by Plasmodium *parasites* .

HY-103353

SID 26681509 4 Publications Verification	Cathepsin Parasite	Infection Cancer
SID 26681509 is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC₅₀ of 56 nM. SID 26681509 inhibits in vitro propagation of malaria parasite *Plasmodium falciparum* and inhibits *Leishmania major* with IC₅₀s of 15.4 μM and 12.5 μM, respectively. SID 26681509 shows no inhibitory activity against cathepsin G .

HY-129476

L-Canaline	Parasite Endogenous Metabolite	Infection Cancer
L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite *Plasmodium falciparum* with an IC₅₀ of 297 nM. L-Canaline has anticancer and antiproliferative effects .

HY-103353A

SID 26681509 quarterhydrate 4 Publications Verification	Cathepsin Parasite	Infection Cancer
SID 26681509 quarterhydrate is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC₅₀ of 56 nM. SID 26681509 quarterhydrate inhibits in vitro propagation of malaria parasite *Plasmodium falciparum* and inhibits *Leishmania major* with IC₅₀s of 15.4 μM and 12.5 μM, respectively. SID 26681509 quarterhydrate shows no inhibitory activity against cathepsin G .

HY-W078844

PfDHODH-IN-2	Dihydroorotate Dehydrogenase Parasite	Infection
PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor with an IC₅₀ of 1.11 µM. PfDHODH-IN-2 acts as an antimalarial agent and can be used for the research of malaria .

HY-125728

Micrococcin P1	Bacterial Parasite HCV	Infection
Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor with an EC₅₀ range of 0.1-0.5 μM . Micrococcin P1 has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Micrococcin P1 against *S. aureus* 1974149, E. faecalis 1674621 and S. pyogenes 1744264 are 2 μg/mL, 1 μg/mL and 1 μg/mL, respectively . Micrococcin P1 is also a potent inhibitor of the malaria *parasite* Plasmodium falciparum .

HY-126323

TCMDC-135051	Parasite	Infection
TCMDC-135051 is a highly selective and potent protein kinase PfCLK3 inhibitor with low off-target toxicity. TCMDC-135051 prevents trophozoite-to-schizont transition, disrupts transcription and reduces transmission to the mosquito vector. TCMDC-135051 has antiparasiticidal activity (EC₅₀=320 nM) .

HY-126323B

TCMDC-135051 hydrochloride	Parasite	Infection
TCMDC-135051 hydrochloride is a highly selective and potent protein kinase PfCLK3 inhibitor with low off-target toxicity. TCMDC-135051 hydrochloride prevents trophozoite-to-schizont transition, disrupts transcription and reduces transmission to the mosquito vector. TCMDC-135051 hydrochloride has antiparasiticidal activity (EC₅₀=320 nM) .

HY-126323A

TCMDC-135051 TFA	Parasite	Infection
TCMDC-135051 TFA is a highly selective and potent protein kinase PfCLK3 inhibitor with low off-target toxicity. TCMDC-135051 TFA prevents trophozoite-to-schizont transition, disrupts transcription and reduces transmission to the mosquito vector. TCMDC-135051 TFA has antiparasiticidal activity (EC₅₀=320 nM) .

HY-143218

TPE-MI 1 Publications Verification Tetraphenylethene maleimide	Huntingtin Parasite	Neurological Disease
TPE-MI (Tetraphenylethene maleimide) is a thiol probe for measuring unfolded protein load and proteostasis in cells. TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasitesPlasmodium falciparum .

HY-N0281

Daphnetin 2 Publications Verification 7,8-Dihydroxycoumarin	EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species Caspase Bcl-2 Family PARP Parasite	Inflammation/Immunology Cancer
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC₅₀s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1ß, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .

TPE-MI 1 Publications Verification Tetraphenylethene maleimide	Fluorescent Dyes/Probes
TPE-MI (Tetraphenylethene maleimide) is a thiol probe for measuring unfolded protein load and proteostasis in cells. TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasitesPlasmodium falciparum .

DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS	Fluorescent Dyes/Probes
DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS is a fluorescent dye, and can be applied in a fluorogenic substrate for an aspartyl proteinase from human malaria parasite .

DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS	Parasite	Others
DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS is a fluorescent dye, and can be applied in a fluorogenic substrate for an aspartyl proteinase from human malaria parasite .

Dabcyl-LNKRLLHETQ-Edans Fluorigenic PEXEL peptide	Peptides	Others
Dabcyl-LNKRLLHETQ-Edans (Fluorigenic PEXEL peptide) is a biological active peptide. (This FRET substrate peptide for Plasmepsin V (PMV) is derived from the conserved Plasmodium Export Element (PEXEL) motif of Histidine-Rich Protein II (HRPII). PMV is an ER aspartic protease that recognizes and cleaves the RXL sequence within the PEXEL motif of proteins exported by human malaria parasite Plasmodium falciparum, allowing them to translocate into host erythrocytes.)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10096

Epoxyazadiradione	Infection Triterpenes other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Biological Pesticide Research Agricultural Research	Parasite
Epoxyazadiradione is a limonoid purified from neem (Azadirachta indica) fruits. Epoxyazadiradione inhibits the tautomerase activity of MIF of both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF)) non-competitively in a reversible fashion (K_i, 2.11-5.23 μM). Epoxyazadiradione has the potential against proinflammatory reactions induced by MIF of both malaria parasites and human .

HY-N8513

Brevicompanine B	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields	Parasite
Brevicompanine B, a diketopiperazine alkaloid, is an antiplasmodial agent. Brevicompanine B is active against the malaria parasite Plasmodium falciparum 3D7 IC₅₀ of 35 mg/mL .

HY-N10624

Koshidacin B	Structural Classification Natural Products Microorganisms	Parasite
Koshidacin B is an antiplasmodial cyclic tetrapeptide with antiplasmodial activity against *P. falciparum* FCR3 and K1 strain with IC₅₀ values of 0.89 and 0.83 μM, respectively. Koshidacin B suppresses malaria parasites in vivo, it can be used for the research of parasites infection .

HY-N10928

Lettowienolide	Quinones Structural Classification Stellaria media (L.) Villars Source classification Phenols Benzene Quinones Plants Caryophyllaceae	Parasite
Lettowienolide, a geranylbenzoquinonoid, exhibits mild in vitro activity against the Plasmodium falciparum malaria parasite (IC₅₀~20 μg/mL) .

HY-N9991

5-Hydroxy-3,7-dimethoxyflavone	Source classification Kaempferia parviflora Wall. ex Baker Plants Zingiberaceae	Others
5-Hydroxy-3,7-dimethoxyflavone (compound 1) can be isolated from Kaempferia parviflora, but has no significant toxicity to malaria parasites, fungi, and bacteria .

HY-129476

L-Canaline	Infection Structural Classification other families Classification of Application Fields Source classification Amino acids Plants Endogenous metabolite Disease Research Fields	Parasite Endogenous Metabolite
L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite *Plasmodium falciparum* with an IC₅₀ of 297 nM. L-Canaline has anticancer and antiproliferative effects .

HY-N0281

Daphnetin 2 Publications Verification 7,8-Dihydroxycoumarin	Classification of Application Fields Daphne Thymelaeaceae Source classification Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species Caspase Bcl-2 Family PARP Parasite
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC₅₀s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1ß, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .

Cat. No.	Product Name	Chemical Structure

HY-13832S2

Atovaquone-d5
Atovaquone-d₅ is the deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

Atovaquone-d5

Atovaquone-d₅ is the deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

HY-13832S3

cis-Atovaquone-d4
cis-Atovaquone-d₄ is deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

cis-Atovaquone-d4

cis-Atovaquone-d₄ is deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

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